<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e47d9-34b7-7297-bcf5-281f8b169d5b,g:ec4e6820-8118-4ac9-9332-3515f563a98f-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://zailab.com/role/Cover" xlink:type="simple" xlink:href="zlab-20260518.xsd#Cover"/>
  <link:presentationLink xlink:role="http://zailab.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019e47d9-34b8-79f4-90c1-b5c5fef0047b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_019e47d9-34b8-728c-9d5b-650ed33ef204" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentInformationTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e47d9-34b8-79f4-90c1-b5c5fef0047b" xlink:to="loc_dei_DocumentInformationTable_019e47d9-34b8-728c-9d5b-650ed33ef204" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019e47d9-34b8-7802-8953-e28120ae5312" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_019e47d9-34b8-728c-9d5b-650ed33ef204" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019e47d9-34b8-7802-8953-e28120ae5312" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019e47d9-34b8-765f-944c-4cf11733d3b9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019e47d9-34b8-7802-8953-e28120ae5312" xlink:to="loc_us-gaap_ClassOfStockDomain_019e47d9-34b8-765f-944c-4cf11733d3b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AdrMember_019e47d9-34b8-777e-b709-eca4c4f0f416" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AdrMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_019e47d9-34b8-765f-944c-4cf11733d3b9" xlink:to="loc_dei_AdrMember_019e47d9-34b8-777e-b709-eca4c4f0f416" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019e47d9-34b8-7cb6-a8a6-0ebdeaa30cf4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_019e47d9-34b8-765f-944c-4cf11733d3b9" xlink:to="loc_us-gaap_CommonStockMember_019e47d9-34b8-7cb6-a8a6-0ebdeaa30cf4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentInformationLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_019e47d9-34b8-728c-9d5b-650ed33ef204" xlink:to="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019e47d9-34b8-75d0-9897-d54bd89e3f91" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_DocumentType_019e47d9-34b8-75d0-9897-d54bd89e3f91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019e47d9-34b8-7b8d-b5a4-c104ad71f75d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_DocumentPeriodEndDate_019e47d9-34b8-7b8d-b5a4-c104ad71f75d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019e47d9-34b8-73df-a7fc-e2c27f264eb4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_EntityRegistrantName_019e47d9-34b8-73df-a7fc-e2c27f264eb4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019e47d9-34b8-7e66-89de-bf33e8643dcc" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019e47d9-34b8-7e66-89de-bf33e8643dcc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019e47d9-34b8-7997-bde5-ac9275953623" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_EntityFileNumber_019e47d9-34b8-7997-bde5-ac9275953623" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019e47d9-34b8-7289-951b-024602902a3f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_EntityTaxIdentificationNumber_019e47d9-34b8-7289-951b-024602902a3f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019e47d9-34b8-755c-9b1b-630431815340" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_EntityAddressAddressLine1_019e47d9-34b8-755c-9b1b-630431815340" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_019e47d9-34b8-7163-a283-feadb1355c17" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_EntityAddressAddressLine2_019e47d9-34b8-7163-a283-feadb1355c17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019e47d9-34b8-7e49-9dc5-2f5b74c58c8f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_EntityAddressCityOrTown_019e47d9-34b8-7e49-9dc5-2f5b74c58c8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCountry_019e47d9-34b8-79a1-827b-a3c9e24af2dc" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCountry"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_EntityAddressCountry_019e47d9-34b8-79a1-827b-a3c9e24af2dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019e47d9-34b8-71d4-954e-b6a7d6bdfa7c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_EntityAddressPostalZipCode_019e47d9-34b8-71d4-954e-b6a7d6bdfa7c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019e47d9-34b8-761d-aab5-f8baa68c7d5a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_CityAreaCode_019e47d9-34b8-761d-aab5-f8baa68c7d5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019e47d9-34b8-76f8-ae88-d70f42974860" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_LocalPhoneNumber_019e47d9-34b8-76f8-ae88-d70f42974860" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019e47d9-34b8-75c4-baa7-10164612f88c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_WrittenCommunications_019e47d9-34b8-75c4-baa7-10164612f88c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019e47d9-34b8-7be9-bd2a-0e912de0d789" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_SolicitingMaterial_019e47d9-34b8-7be9-bd2a-0e912de0d789" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019e47d9-34b8-72ca-b557-09529dfee8ab" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_PreCommencementTenderOffer_019e47d9-34b8-72ca-b557-09529dfee8ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019e47d9-34b8-7ece-b479-a16dc135fb47" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019e47d9-34b8-7ece-b479-a16dc135fb47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019e47d9-34b8-7d40-b2dd-7f2c8348e5ec" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_Security12bTitle_019e47d9-34b8-7d40-b2dd-7f2c8348e5ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019e47d9-34b8-7902-85c5-f87eb63225de" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_TradingSymbol_019e47d9-34b8-7902-85c5-f87eb63225de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019e47d9-34b8-74bd-95a3-ecab58433995" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_SecurityExchangeName_019e47d9-34b8-74bd-95a3-ecab58433995" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019e47d9-34b8-78d5-8b13-30eae23e31e6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_EntityEmergingGrowthCompany_019e47d9-34b8-78d5-8b13-30eae23e31e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019e47d9-34b8-7926-baac-0879dfbce539" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_AmendmentFlag_019e47d9-34b8-7926-baac-0879dfbce539" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019e47d9-34b8-7838-bedc-3b1c20d125ae" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019e47d9-34b8-7580-ad86-369da0127125" xlink:to="loc_dei_EntityCentralIndexKey_019e47d9-34b8-7838-bedc-3b1c20d125ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
